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Low Carb Diet May Reverse Age-Related Effects Within the Brain

Lilianne R. Mujica-Parodi

The news in brief:

1) Brain changes associated with aging become visible much earlier than would be expected, in the late 40’s.

2) This is hypothesized to result from neurons’ loss of energy; if so, researchers may have found a way to prevent or reverse these effects.

3) This can be done with diet, by switching neurons’ fuel from glucose to ketones. Ketones have previously been shown to increase the availability of energy to the heart. However, this is the first evidence that a similar benefit may be achieved for the brain.

Study Shows Low Carb Diet May Prevent, Reverse Age-Related Effects Within the Brain

STONY BROOK, NY, March 4, 2020 A study using neuroimaging led by Stony Brook University professor and lead author Lilianne R. Mujica-Parodi, PhD, and published in PNAS, reveals that neurobiological changes associated with aging can be seen at a much younger age than would be expected, in the late 40s. However, the study also suggests that this process may be prevented or reversed based on dietary changes that involve minimizing the consumption of simple carbohydrates.

Mujica parodi 2020web
Lilianne R. Mujica-Parodi, Ph.D.

To better understand how diet influences brain aging, the research team focused on the presymptomatic period during which prevention may be most effective. In the article titled “Diet modulates brain network stability, a biomarker for brain aging, in young adults,” they showed, using large-scale life span neuroimaging datasets, that functional communication between brain regions destabilizes with age, typically in the late 40’s, and that destabilization correlates with poorer cognition and accelerates with insulin resistance. Targeted experiments then showed this biomarker for brain aging to be reliably modulated with consumption of different fuel sources: glucose decreases, and ketones increase, the stability of brain networks. This effect was replicated across both changes to total diet as well as after drinking a fuel-specific calorie-matched supplement.

“What we found with these experiments involves both bad and good news,” said Mujica-Parodi, a Professor in the Department of Biomedical Engineering with joint appointments in the College of Engineering & Applied Sciences and Renaissance School of Medicine at Stony Brook University, and a faculty member in the Laufer Center for Physical and Quantitative Biology. “The bad news is that we see the first signs of brain aging much earlier than was previously thought. However, the good news is that we may be able to prevent or reverse these effects with diet, mitigating the impact of encroaching hypometabolism by exchanging glucose for ketones as fuel for neurons.”

What the researchers discovered, using neuroimaging of the brain, is that quite early on there is breakdown of communication between brain regions (“network stability”).

“We think that, as people get older, their brains start to lose the ability to metabolize glucose efficiently, causing neurons to slowly starve, and brain networks to destabilize,” said Mujica-Parodi. “Thus, we tested whether giving the brain a more efficient fuel source, in the form of ketones, either by following a low-carb diet or drinking ketone supplements, could provide the brain with greater energy. Even in younger individuals, this added energy further stabilized brain networks.”

To conduct their experiments, brain network stability was established as a biomarker for aging by using two large-scale brain neuroimaging (fMRI) datasets totaling nearly 1,000 individuals, ages 18 to 88. Destabilization of brain networks was associated with impaired cognition and was accelerated with Type 2 diabetes, an illness that blocks neurons’ ability to effectively metabolize glucose. To identify the mechanism as being specific to energy availability, the researchers then held age constant and scanned an additional 42 adults under the age of 50 years with fMRI. This allowed them to observe directly the impact of glucose and ketones on each individual’s brain.

The brain’s response to diet was tested in two ways. The first was holistic, comparing brain network stability after participants had spent one week on a standard (unrestricted) vs. low carb (for example: meat or fish with salad, but no sugar, grains, rice, starchy vegetables) diet. In a standard diet, the primary fuel metabolized is glucose, whereas in a low-carb diet, the primary fuel metabolized is ketones. However, there might have been other differences between diets driving the observed effects. Therefore, to isolate glucose vs. ketones as the crucial difference between the diets, an independent set of participants was scanned before and after drinking a small dose of glucose on one day, and ketones on the other, where the two fuels were individually weight-dosed and calorically matched. The results replicated, showing that the differences between the diets could be attributed to the type of fuel they provide to the brain.

Additional findings from the study included the following: Effects of brain aging emerged at age 47, with most rapid degeneration occurring at age 60. Even in younger adults, under age 50, dietary ketosis (whether achieved after one week of dietary change or 30 minutes after drinking ketones) increased overall brain activity and stabilized functional networks. This is thought to be due to the fact that ketones provide greater energy to cells than glucose, even when the fuels are calorically matched. This benefit has previously been shown for the heart, but the current set of experiments provides the first evidence for equivalent effects in the brain.

“This effect matters because brain aging, and especially dementia, are associated with “hypometabolism,” in which neurons gradually lose the ability to effectively use glucose as fuel. Therefore, if we can increase the amount of energy available to the brain by using a different fuel, the hope is that we can restore the brain to more youthful functioning. In collaboration with Dr. Eva Ratai at Massachusetts General Hospital, we’re currently addressing this question, by now extending our studies to older populations,” said Mujica-Parodi.

“Additional research with collaborators at Children’s National, under the direction of Dr. Nathan Smith, focuses on discovering the precise mechanisms by which fuel impacts signaling between neurons. Finally, in collaboration with Dr. Ken Dill and Dr. Steven Skiena, at Stony Brook, we’re working on building a comprehensive computational model that can incorporate our understanding of the biology, from individual neurons to whole brains to cognition, as it develops.”

The research is currently funded under a new $2.5 million National Science Foundation BRAIN Initiative “Frontiers” grants (numbers (NSFECCS1533257 and NSFNCS-FR 1926781) awarded to Stony Brook, as well as by the W. M. Keck Foundation, which originally funded the team in 2017 with a $1 million seed grant designed to jump-start “pioneering discoveries in science, engineering, and medical research.”

Collaborators included Stony Brook faculty from the Laufer Center for Physical and Quantitative Biology, Departments of Biomedical Engineering, Applied Mathematics and Statistics, Physics and Astronomy, and Computer Science; and scientists at the Athinoula A. Martinos Center for Biomedical Imaging (Massachusetts General Hospital and Harvard Medical School), Children’s National, the National Institutes of Health, and Oxford University.

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  • What I don’t understand is why the results of this study should ever come as a surprise. We *evolved* over hundreds of thousands of years living on very low carb diets in the wild, often fasting not because we wanted to, but because we had to. Fats and proteins were usually our only source of nutrition. Our ancestors were *always* in ketosis. We are evolved to live on ketones, that’s our body’s normal state, that’s what our genetics expect, and that’s what our brains prefer. They will burn glucose if it’s available not because it prefers it in the sense that it is better for it, but because during fight or flight, the liver would produce/release simple carbs to fuel the fight/flight response, and the brain evolved to take glucose if it were available as part of that response. Today, many consider a low carb or no carb diet as ‘extreme’ — that’s only because we’ve grown up having access to an obnoxiously massive amount of carbs on an daily basis, able to obtain simple sugars on a moment’s notice. There were no Snicker’s bars or Big Gulps on the savannas. We didn’t have easy, consistent access to carbs, especially simple carbs, in any form during our evolution, but today we think putting sugar in our tea or coffee is normal and ok. (By carbs, I mean simple sugars, and starches — not the very complex carbs you get from something like an onion or celery. But also note that today’s vegetables, even root vegetables, are bred to be much ‘sweeter’ carb-wise than wild roots and berries and other plant foods that were available in our past.)

    • Well said Scott, totally agree. It seems most of us have to “discover” our own history. Pretty silly. But if research and articles like this will influence more people to return to that way of eating, I’m happy.

  • THE END OF ALZHEIMER’S, by Dr. Dale Bredesden, MD, c.2017, covers a lot of research about this, and includes the lifestyle changes that are an effective “shotgun approach” to preventing, halting, even reversing mental decline, as opposed to what has been the emphasis in much of research that is looking for a one-time “silver bullet cure” approach, which does not exist.

  • Ok this does it for me. I resisted the whole low-carb movement long enough. I’m beginning the switch for real this time.

  • I’d be really curious to see where the funding for this study is really coming from….meat industry trying to protect their ever declining profits no doubt

  • Another example of junk science. Yes, they once again proved that anything is better than eating pure sugar (or it’s near equivalent, the SAD). Every single group of people in the world who traditionally remain cognitively and physically excellent into their late 90’s and even past 100 eat a primarily plant based diet. There are none who eat a meat based diet. If a researcher wants to show something as superior, they should compare to the proven best, not to the proven worst.

    Counter to some of the comments, we evolved eating primarily a plant based diet and those primates most closely related to us still do in the wild.

    The “low carb” diets, like the Atkins have proven repeatedly to be a disaster in the past (Atkins himself died obese with widespread heart disease) and studies now are showing the keto diet to have undesirable effects after a short time. I’ll take lifelong studies any day over short term flawed studies – see the “Blue Zones” studies for what works in real life.

    • Every one of your points is biased, using Atkins is not an example of a proper Ketogenic diet for one. Two there is no plant based diet proof, this is only theory and there are others just as valid and more likely. Humans evolved more during times when only meat was available, Ice Ages. Cows, the teeth, the stomach, See I can throw out just as much stuff countering your attempt at attacking a scientific study you are denying.

  • That info has been around for decades . . . Good that its getting publicity . . . BIG food companies will try to bury it though.

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